Study of Alteplase for Respiratory Failure in SARS-CoV-2 COVID-19

• DOI: 10.1016/j.chest.2021.09.024
• Publication Date: 2021-09-27T18:52:45Z
• Authors: Christopher D. Ba...; Hunter B. Moore; Ernest E. Moore; Janice Wang; Negin Hajizadeh; Walter L. Biffl; Lawrence Lottenberg; Purvesh R. Patel; Michael S. Truitt; Robert C. McIntyre; Todd M. Bull; Lee Anne Ammons; Arsen Ghasabyan; James Chandler; Ivor S. Douglas; Eric P. Schmidt; Peter K. Moore; Franklin L. Wright; Ramona Ramdeo; Robert Borrego; Mario Rueda; Achal Dhupa; D. Scott McCaul; Tala Dandan; Pralay K. Sarkar; Benazir Khan; Coimbatore Sreevidya; Conner McDaniel; Heather M. Grossm...; Christopher Pearcy; Lorenzo Anez-Bust...; Elias N. Baedorf-...; Rashi Jhunjhunwala; Shahzad Shaefi; Krystal Capers; Valerie Banner-Go...; Daniel S. Talmor; Angela Sauaia; Michael B. Yaffe
• Keywords: 2019-20 coronavirus outbreak; Acute respiratory failure

Pulmonary vascular microthrombi are a proposed mechanism of COVID-19 respiratory failure. We hypothesized that early administration tissue plasminogen activator (tPA) followed by therapeutic heparin would improve pulmonary function in these patients.