Upper and lower respiratory tract correlates of protection against respiratory syncytial virus following vaccination of nonhuman primates

• DOI: 10.1016/j.chom.2021.11.006
• Publication Date: 2021-12-07T16:14:09Z
• Authors: Tomer Zohar; Jeff C. Hsiao; Nickita Mehta; Jishnu Das; Anush Devadhasan; Wiktor Karpinski; Cheryl Callahan; Michael P. Citron; Daniel J. DiStefano; Sinoeun Touch; Zhiyun Wen; Jeffrey R. Sachs; Pedro J. Cejas; Amy S. Espeseth; Douglas A. Lauffe...; Andrew J. Bett; Galit Alter
• Keywords: Respiratory tract

Respiratory syncytial virus (RSV) infection is a major cause of respiratory illness in infants and the elderly. Although several vaccines have been developed, none succeeded part due to our incomplete understanding correlates immune protection. While both T cells antibodies play role, emerging data suggest that antibody-mediated mechanisms alone may be sufficient provide Therefore, map humoral immunity against RSV, antibody responses across six different were profiled highly controlled nonhuman primate-challenge model. Viral loads monitored upper lower tracts, machine learning was used determine vaccine platform-agnostic features associated with Upper control virus-specific IgA levels, neutralization, complement activity, whereas Fc-mediated effector mechanisms. These findings critical compartment-specific insights toward rational development future vaccines.