Antigenic cartography of well-characterized human sera shows SARS-CoV-2 neutralization differences based on infection and vaccination history

• DOI: 10.1016/j.chom.2022.10.012
• Publication Date: 2022-10-21T08:06:08Z
• Authors: Wei Wang; Sabrina Lusvarghi; Rahul Subramanian; Nusrat J. Epsi; Richard Wang; Emilie Goguet; Anthony C. Fries; Fernando Echegaray; Russell Vassell; Si’Ana A. Coggins; Stephanie A. Richard; David A. Lindholm; Katrin Mende; Evan C. Ewers; Derek T. Larson; Rhonda E. Colombo; Christopher J. Co...; Janet O. Joseph; Julia S. Rozman; Alfred Smith; Tahaniyat Lalani; Catherine M. Berjohn; Ryan C. Maves; Milissa U. Jones; Rupal Mody; Nikhil Huprikar; Jeffrey Livezey; David Saunders; Monique Hollis-Perry; Gregory Wang; Anuradha Ganesan; Mark P. Simons; Christopher C. Br...; David R. Tribble; Eric D. Laing; Brian K. Agan; Timothy H. Burgess; Edward Mitre; Simon D. Pollett; Leah C. Katzelnick; Carol D. Weiss
• Keywords: 0301 basic medicine; 03 medical and health sciences; COVID-19 Vaccines; SARS-CoV-2; Vaccination; Humans; COVID-19; Antibodies, Viral; Antibodies, Neutralizing; Article; 3. Good health

The rapid emergence of SARS-CoV-2 variants challenges vaccination strategies. Here, we collected 201 serum samples from persons with a single infection or multiple vaccine exposures, both. We measured their neutralization titers against 15 natural and 7 engineered spike mutations analyzed antigenic diversity. Antigenic maps primary sera showed that Omicron sublineages BA.2, BA.4/BA.5, BA.2.12.1 are distinct BA.1 more similar to Beta/Gamma/Mu variants. Three mRNA COVID-19 vaccinations increased than BA.4/BA.5 BA.2.12.1. post-vaccination elicited higher all three alone, although less BA.4/BA.5. Those after two had titer magnitude recognition. Accounting for differences among when interpreting can aid the understanding complex patterns in humoral immunity informs selection future strains.