IL-10-producing regulatory cells impact on celiac disease evolution

• DOI: 10.1016/j.clim.2024.109923
• Publication Date: 2024-02-04T01:48:38Z
• Authors: Laura Passerini; Giada Amodio; Virginia Bassi; Serena Vitale; Ilaria Mottola; Marina Di Stefano; Lorella Fanti; Paola Sgaramella; Chiara Ziparo; Silvia Furio; Renata Auricchio; Graziano Barera; Giovanni Di Nardo; Riccardo Troncone; Carmen Gianfrani; Silvia Gregori
• Keywords: Gliadin; Intestinal mucosa

Celiac Disease (CD) is a T-cell mediated disorder caused by immune response to gluten, although the mechanisms underlying CD progression are still elusive. We analyzed cell composition, plasma cytokines, and gliadin-specific responses in patients with positive serology normal intestinal mucosa (potential-CD) or villous atrophy (acute-CD), after gluten-free diet (GFD). found: an inflammatory signature presence of circulating IFN-γ