Visual evoked potentials in multiple sclerosis: P100 latency and visual pathway damage including the lateral geniculate nucleus

• DOI: 10.1016/j.clinph.2024.02.020
• Publication Date: 2024-02-20T20:56:50Z
• Authors: Athina Papadopoulou; Armanda Pfister; Charidimos Tsagkas; Laura Gaetano; Shaumiya Sellathurai; Marcus D'Souza; Nuria Cerdá-Fuertes; Konstantin Gugleta; Maxime Descoteaux; Mallar M. Chakrav...; Peter Fuhr; Ludwig Kappos; Cristina Granziera; Stefano Magon; Till Sprenger; Martin Hardmeier
• Keywords: Lateral geniculate nucleus; Optic neuritis

To explore associations of the main component (P100) visual evoked potentials (VEP) to pre- and postchiasmatic damage in multiple sclerosis (MS). 31 patients (median EDSS: 2.5), 13 with previous optic neuritis (ON), healthy controls had VEP, optical coherence tomography magnetic resonance imaging. We tested P100-latency peripapillary retinal nerve fiber layer (pRNFL), ganglion cell/inner plexiform layers (GCIPL), lateral geniculate nucleus volume (LGN), white matter lesions radiations (OR-WML), fractional anisotropy non-lesional (NAOR-FA), mean thickness primary cortex (V1). Effect sizes are given as marginal R2 (mR2). P100-latency, pRNFL, GCIPL LGN differed from controls. Within patients, was significantly associated (mR2= 0.26), less strongly OR-WML (mR2=0.17), NAOR-FA (mR2=0.13) pRNFL (mR2=0.08). In multivariate analysis, remained (mR2=0.41). ON-patients, (mR2=-0.56). is affected by anterior posterior pathway damage. at synapse-level (LGN) may additionally contribute latency delay. Our findings corroborate post-chiasmatic contributions VEP-signal, which relate distinct pathophysiological mechanisms MS.