Dietary zinc intake and incident chronic kidney disease

• DOI: 10.1016/j.clnu.2020.07.005
• Publication Date: 2020-07-15T07:32:45Z
• Authors: Young Su Joo; Hyung Woo Kim; Sangmi Lee; Ki Heon Nam; Hae-Ryong Yun; Jong Hyun Jhee; Seung Hyeok Han; Tae-Hyun Yoo; Shin-Wook Kang; Jung Tak Park
• Keywords: Quartile

Background & aimsPrevious studies have shown that dietary zinc intake is closely related to cardiovascular complications and metabolic derangements. However, the effect of on renal function not fully elucidated.MethodsData from Korean Genome Epidemiology Study were used. Dietary was assessed by a Food Frequency Questionnaire density calculated as absolute amount per daily energy (mg/1000 kcal day). The participants categorized into quartiles according density. primary end point incident chronic kidney disease (CKD), defined estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2.ResultsA total 7735 with normal included in final analysis. mean age 52.0 ± 8.8 years, 47.5% male, eGFR 92.1 16.1 m2. 8.6 3.4 mg 4.4 0.9 mg/1000 kcal, respectively. During median follow up 11.5 (1.7–12.5) years 70,617 person-years observation, CKD developed 1409 (18.2%) participants. Multivariable cox hazard analysis revealed risk for development significantly higher quartile 3.6 0.2 compared 5.6 1.0 (Hazard ratio; 1.36; 95% Confidence Interval 1.18–1.58; P 0.001). This relationship remained significant even after adjustments confounding factors.ConclusionLow may increase individuals function.