A double-blinded, randomized, parallel intervention to evaluate biomarker-based nutrition plans for weight loss: The PREVENTOMICS study

• DOI: 10.1016/j.clnu.2022.06.032
• Publication Date: 2022-06-30T15:52:25Z
• Authors: Mona A. Aldubayan; Kristina Pigsborg; Sophia M.O. Gormsen; Francisca Serra; Mariona Palou; Sebastià Galmés; Andreu Palou-March; Claudia Favari; Mart Wetzels; Alberto Calleja; Miguel Angel Rodr...; María Guirro Cast...; Antoni Caimari; Mar Galofré; David Suñol; Xavier Escoté; Juan María Alcaid...; Josep M del Bas; Biotza Gutierrez; Thure Krarup; Mads F. Hjorth; Faidon Magkos
• Keywords: Adult; 0301 basic medicine; Health-biomarker; Metabolomic; SDG 3 – Goede gezondheid en welzijn; 796; Body Mass Index; 03 medical and health sciences; SDG 3 - Good Health and Well-being; Weight management; Weight Loss; Faculty of Science; Metabolomics; Humans; Obesity; /dk/atira/pure/core/keywords/TheFacultyOfScience; Nutrigenetics; 2. Zero hunger; Body Weight; Personalized nutrition; Precision nutrition; Overweight; Lipids; 3. Good health; Health-biomarkers; Nutrigenetic; Biomarkers

Growing evidence suggests that biomarker-guided dietary interventions can optimize response to treatment. In this study, we evaluated the efficacy of PREVENTOMCIS platform-which uses metabolomic and genetic information classify individuals into different 'metabolic clusters' create personalized plans-for improving health outcomes in subjects with overweight or obesity.A 10-week parallel, double-blinded, randomized intervention was conducted 100 adults (82 completers) aged 18-65 years, body mass index ≥27 but <40 kg/m2, who were allocated either a diet group (n = 49) control 51). About 60% all food provided free-of-charge. No specific instruction restrict energy intake given. The primary outcome change fat from baseline, by dual X-ray absorptiometry. Other endpoints included weight, waist circumference, lipid profile, glucose homeostasis markers, inflammatory blood pressure, physical activity, stress eating behavior.There significant main effects time (P < 0.01), no effects, time-by-group interactions, for (personalized: -2.1 [95% CI -2.9, -1.4] kg; control: -2.0 -2.7, -1.3] kg) weight -3.1 -4.1, -2.1] -3.3 -4.2, -2.4] kg). difference between groups -0.1 kg (95% -1.2, 0.9 kg, P 0.77). Both diets resulted improvements insulin resistance there differences groups.Personalized plans did not result greater benefits over generic, generally healthy diet, clinical trial. Further studies are required establish soundness precision nutrition approaches, translate science clinically relevant advice reduce burden obesity its comorbidities.ClinicalTrials.gov registry (NCT04590989).