Rich oleocanthal and oleacein extra virgin olive oil and inflammatory and antioxidant status in people with obesity and prediabetes. The APRIL study: A randomised, controlled crossover study

• DOI: 10.1016/j.clnu.2023.06.027
• Publication Date: 2023-06-28T07:38:23Z
• Authors: Ignacio Ruiz-García; Rodolfo Ortíz-Flores; Rocío Badía; Aranzazu García-B...; María García-Fern...; Estrella Lara; Elisa Martín-Mont...; Sara García-Serrano; Sergio Valdés; Montserrat Gonzalo; María-José Tapia-...; José-Carlos Ferná...; Alicia Sánchez-Ga...; Francisca Muñoz-C...; Miguel Calderón-Cid; Rajaa El-Bekay; María-Isabel Covas; Gemma Rojo-Martínez; Gabriel Olveira; Silvana-Yanina Ro...; Francisco-Javier ...
• Keywords: Prediabetes; Crossover study

Oleocanthal and oleacein are olive oil phenolic compounds with well known anti-inflammatory anti-oxidant properties. The main evidence, however, is provided by experimental studies. Few human studies have examined the health benefits of oils rich in these biophenols. Our aim was to assess properties oleocanthal extra virgin (EVOO), compared those common (OO), people prediabetes obesity.Randomised, double-blind, crossover trial done aged 40-65 years obesity (BMI 30-40 kg/m2) (HbA1c 5.7-6.4%). intervention consisted substituting for 1 month used food, both raw cooked, EVOO or OO. No changes diet physical activity were recommended. primary outcome inflammatory status. Secondary outcomes oxidative status, body weight, glucose handling lipid profile. An ANCOVA model adjusted age, sex treatment administration sequence statistical analysis.A total 91 patients enrolled (33 men 58 women) finished trial. A decrease interferon-γ observed after treatment, reaching inter-treatment differences (P = 0.041). Total antioxidant status increased organic peroxides decreased significance OO < 0.05). Decreases BMI blood (p 0.05) found not OO.Treatment differentially improved prediabetes.