A fluid–solid-growth solver for cardiovascular modeling

• DOI: 10.1016/j.cma.2023.116312
• Publication Date: 2023-08-09T20:17:11Z
• Authors: Erica L. Schwarz; Martin R. Pfaller; Jason M. Szafron; Marcos Latorre; Stephanie E. Lindsey; Christopher K. Br...; Jay D. Humphrey; Alison L. Marsden
• Keywords: Computational Engineering, Finance, and Science (cs.CE); FOS: Computer and information sciences; Computer Science - Computational Engineering, Finance, and Science

We implement full, three-dimensional constrained mixture theory for vascular growth and remodeling into a finite element fluid-structure interaction (FSI) solver. The resulting "fluid-solid-growth" (FSG) solver allows long term, patient-specific predictions of changing hemodynamics, vessel wall morphology, tissue composition, and material properties. This extension from short term (FSI) to long term (FSG) simulations increases clinical relevance by enabling mechanobioloigcally-dependent studies of disease progression in complex domains.<br/>36 pages, 11 figures<br/>