Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis

• DOI: 10.1016/j.cmet.2021.12.016
• Publication Date: 2022-01-13T15:38:08Z
• Authors: Shogo Sato; Kenneth A. Dyar; Jonas T. Treebak; Sara L. Jepsen; Amy M. Ehrlich; Stephen P. Ashcroft; Kajetan Trost; Thomas Kunzke; Verena M. Prade; Lewin Small; Astrid Linde Basse; Milena Schönke; Siwei Chen; Muntaha Samad; Pierre Baldi; Romain Barrès; Axel Walch; Thomas Moritz; Jens J. Holst; Dominik Lutter; Juleen R. Zierath; Paolo Sassone-Corsi
• Keywords: Homeostasis

Tissue sensitivity and response to exercise vary according the time of day alignment circadian clocks, but optimal elicit a desired metabolic outcome is not fully defined. To understand how tissues independently collectively respond timed exercise, we applied systems biology approach. We mapped compared global metabolite responses seven different mouse serum after an acute bout performed at times day. Comparative analyses intra- inter-tissue dynamics, including temporal profiling blood sampling across liver hindlimb muscles, uncovered unbiased view local systemic unique This comprehensive atlas metabolism provides clarity physiological context regarding production distribution canonical novel time-dependent exerkine metabolites, such as 2-hydroxybutyrate (2-HB), reveals insight into health-promoting benefits on metabolism.