Phoma (Peyronellaea) spp.: a phytopathogen as a cause of cystic phaeohyphomycosis in a diabetic patient

• DOI: 10.1016/j.cmi.2019.08.008
• Publication Date: 2019-08-22T00:41:25Z
• Authors: R.P. Nolêto; I.S. Santos; T.G. Amaro; D. Diebold; G. Vettorato; T.C. Daboit
• Keywords: Phaeohyphomycosis; Hyaline; Phoma

A 63-year-old man with type 2 diabetes, resident on the north coast, Rio Grande do Sul, Brazil, was referred to dermatology health service at Santa Casa de Porto Alegre due a nodular subcutaneous lesion left ankle (Fig. 1a) in May 2012. He underwent direct and cultural mycological examinations, former, septate hyphae were detected 1b). In latter, material from injury inoculated Mycosel Sabouraud agar chloramphenicol incubated for 15 days 35°C. This showed growth of filamentous fungus initial hyaline aspect, but becoming dematiaceous over time 1c). The colonies obtained submitted microculture technique, through which fruiting structures presence pycnidia observed 1d). Sequencing ITS1-5.8S rDNA-ITS2 performed using universal primers. Sequences analysed MEGA 7.0 indicated phaeohyphomycosis caused by Phoma (Peyronellaea) spp. With this diagnosis, treatment itraconazole 200 mg/day initiated, together application hot compresses site. During 4 months therapy there progressive regression disease. Surgical removal cyst not because patient diabetic anatomical location favourable. Phaeohyphomycosis is term used describe group heterogeneous mycotic diseases several fungal microorganisms. Being an uncommon condition, disease under-diagnosed, affecting directly success high rate mortality when dissemination occurs. form ubiquitous phytopathogens found soil organic matter. These pathogens have been identified as cause opportunistic infections humans animals. Until now, 32 reports literature human [[1]Bennett A. Ponder M.M. Garcia-Diaz J. infections: classification, potential food sources, their clinical impact.Microorganisms. 2018; 58: 1-12Google Scholar]. There no external funding study.