Supramolecular control on reactivity and selectivity inside the confined space of H-bonded hexameric capsules

• DOI: 10.1016/j.cocis.2023.101692
• Publication Date: 2023-03-22T07:43:37Z
• Authors: Veronica Iuliano; Paolo Della Sala; Carmen Talotta; Margherita De Rosa; Annunziata Soriente; Carmine Gaeta; Placido Neri
• Keywords: Reactivity; Resorcinarene; Confined space

The confinement of substrates inside the cavity self-assembled capsules makes it possible to effectively catalyze organic reactions in a way that is analogous how enzymes work biological systems. Due steric constraints, solvent exclusion, intermediates stabilization, and conformational control substrates, chemical taking place confined space may exhibit unique processes. As result, fundamental rules reactivity are frequently broken. hexameric capsule CR, an intriguing supramolecular assembly formed by six resorcinarene 1 macrocycles eight water molecules, subject this review. This has proven be effective at catalyzing several controlling selectivity its space.