RASSF1 and PTEN Promoter Hypermethylation Influences the Outcome in Epithelial Ovarian Cancer

• DOI: 10.1016/j.cogc.2014.12.002
• Publication Date: 2015-01-22T18:24:21Z
• Authors: Mariyam Zuberi; Rashid Mir; Sagar Dholariya; Imtiyaz Najar; Prasant Yadav; Jamsheed Javid; Sameer Guru; Masroor Mirza; Gauri Gandhi; Nita Khurana; Prakash C. Ray; Alpana Saxena
• Keywords: CpG islands; 03 medical and health sciences; 0302 clinical medicine; Clinicopathological; Methylation-specific PCR; Prognosis; Tumor Suppressor Gene; 3. Good health

To investigate the methylation pattern in promoter region of RASSF1A and PTEN genes epithelial ovarian cancer patients North India. Fifty 20 healthy controls were studied. Isolation genomic DNA from peripheral blood methylation-specific polymerase chain reaction (MSP) applied for analysis. 17 50 (34.0%) found to be methylated gene, whereas gene occurred 8 cases (16.0%). A statistically significant result was obtained (P = .01) correlated with patients' clinicopathologic features. Hypermethylation both might offer an exposition early diagnosis malignancy.