Rapid synthesis of magnetic polyimine nanospheres at room temperature for enrichment of endogenous C-peptide

• DOI: 10.1016/j.colcom.2021.100390
• Publication Date: 2021-03-21T00:36:21Z
• Authors: Zhiyu Li; Huinan Zhang; Yue Zhu; Bin Luo; Jia He; Fang Lan; Yao Wu
• Keywords: Superparamagnetism; Reusability; Prussian blue

Abstract A superparamagnetic polyimine nanosphere was synthesized by a facile and fast method at room temperature. The as-prepared nanospheres exhibited good physicochemical properties, resulting in outstanding performances in C-peptide enrichment with high detection sensitivity (0.1 fmol/μL), excellent reusability (at least six times) and size-exclusion effect (C-peptide/Cyt-C). Additionally, ultratrace C-peptide from human serum was clearly identified. This work provides a strategy for room temperature fast preparation of magnetic polyimine nanospheres, uniform and thick polyimine coating, showing the enormous potential of magnetic polyimine in clinical analysis.