Application of magnetic iron oxide nanoparticles: Thrombotic activity, imaging and cytocompatibility of silica-coated and carboxymethyl dextrane-coated particles

• DOI: 10.1016/j.colsurfb.2023.113428
• Publication Date: 2023-06-24T20:19:15Z
• Authors: Chiara Turrina; Max Schoenen; Davide Milani; Anna Klassen; Diana M. Rojas Go...; Gerhard Cvirn; Petra Mela; Sonja Berensmeier; Ioana Slabu; Sebastian P. Schw...
• Keywords: Biocompatibility; Simulated body fluid; Iron oxide nanoparticles

Coated iron oxide nanoparticles (IONs) are promising candidates for various applications in nanomedicine, including imaging, magnetic hyperthermia, and drug delivery. The application of IONs nanomedicine is influenced by factors such as biocompatibility, surface properties, agglomeration, degradation behavior, thrombogenicity. Therefore, it essential to investigate the effects coating material thickness on behavior performance human body. In this study, with a carboxymethyl dextran (CMD) two thicknesses silica (TEOS0.98, TEOS3.91) were screened compared bare (BIONs). All three coated particles showed good cytocompatibility (>70%) when tested smooth muscle cells over days. To their potential long term inside body, Fe2+ release hydrodynamic diameters silica-coated CMD (carboxymethyl dextrane)-coated analyzed simulated body fluids 72 h at 37 °C. ION@CMD moderate agglomeration around 100 nm all four dissolved faster than artificial exosomal fluid lysosomal fluid. agglomerated media above 1000 nm. Increased led decreased particles. Additionally, resulted least prothrombotic activity, thick apparently properties BIONs ION@TEOS0.98. For resonance applications, ION@TEOS3.91 comparatively high relaxation rates R2 values. particle imaging experiments yielded highest normalized signal noise ratio values hyperthermia studies, ION@TEOS0.98 similar specific loss power. These findings demonstrate emphasize importance understanding effect