Endoplasmic reticulum stress in pancreatic β-cell dysfunction: The potential therapeutic role of dietary flavonoids

• DOI: 10.1016/j.crphar.2024.100184
• Publication Date: 2024-05-24T16:49:22Z
• Authors: Kingsley C. Mbara; Marthe C.D. Fotsing; Derek T. Ndinteh; Claudine N. Mbeb; Chinekwu S. Nwagwu; Rene Khan; Kopang C. Mokhetho; Himansu Baijnath; Manimbulu Nlooto; Shoeshoe Mokhele; Carmen M. Leonard; Vuyelwa J. Tembu; Clemence Tarirai
• Keywords: Flavonoids; Unfolded protein response; 0301 basic medicine; 03 medical and health sciences; Diabetes; Endoplasmic reticulum stress; β-cells; Molecular mechanisms; Therapeutics. Pharmacology; RM1-950; Article

Diabetes mellitus (DM) is a global health burden that characterized by the loss or dysfunction of pancreatic β-cells. In β-cells, endoplasmic reticulum (ER) stress fact life contributes to β-cell dysfunction. Despite recent advances in research, existing treatment approaches such as lifestyle modification and use conventional therapeutics could not prevent β-cells abrogate disease progression. Therefore, targeting ER consequent unfolded protein response (UPR) may be potential therapeutic strategy for diabetes treatment. Dietary phytochemicals have applications human owing their broad spectrum biochemical pharmacological activities. Flavonoids, which are commonly obtained from fruits vegetables worldwide, shown promising prospects alleviating stress. flavonoids including quercetin, kaempferol, myricetin, isorhamnetin, fisetin, icariin, apigenin, apigetrin, vitexin, baicalein, baicalin, nobiletin hesperidin, naringenin, epigallocatechin 3-O-gallate hesperidin (EGCG), tectorigenin, liquiritigenin, acacetin inhibitory effects on modulate signaling components, chaperone proteins, transcription factors, oxidative stress, autophagy, apoptosis, inflammatory responses exert This review focuses role dietary adjuvants preserving Highlights underlying mechanisms action also presented well possible strategies clinical translation management DM.