Co-occurrence of a Mullerian anomaly and Kallmann syndrome: A case report

• DOI: 10.1016/j.crwh.2025.e00692
• Publication Date: 2025-02-04T16:35:39Z
• Authors: Lea C. George; Rebecca Gendelman; Anat Chemerinski; Pierre Lespinasse; Inessa A. Goldman; Sara Morelli
• Keywords: Müllerian mimicry; Anomaly (physics)

The evaluation of primary amenorrhea requires a thoughtful assessment for hormonal, structural and/or genetic causes. Although most cases are caused by single pathology, rarely multiple pathologies may be uncovered. We present the case 33-year-old woman with history pubertal failure and due to Kallmann syndrome. She reported previous short-term use hormone replacement therapy, onset severe pelvic pain vaginal bleeding following its discontinuation. Her workup revealed concern uterine didelphys OHVIRA syndrome on MRI. Surgical exploration normal-appearing vagina cervix communicating left horn fallopian tube, separate, contralateral, obstructed, engorged right obstructed vagina, normal ovaries bilaterally. underwent laparoscopic resection hemiuterus salpingectomy. Estrogen therapy was initiated postoperatively cyclic progestins, she experienced complete resolution her pain. In amenorrhea, it is important consider that more than one pathology present. A thorough endocrine, genetic, anatomic imperative prior confirming diagnosis initiating treatment. has been Mullerian anomalies; in this represents scenario which induction puberty menses brought an obstructive anomaly light. possibility co-occurring should always considered provide optimal care patient.