Genetic profiling for diffuse type and genomically stable subtypes in gastric cancer

• DOI: 10.1016/j.csbj.2020.10.021
• Publication Date: 2020-10-30T11:41:05Z
• Authors: Yiwei Ling; Yu Watanabe; Masayuki Nagahashi; Yoshifumi Shimada; Hiroshi Ichikawa; Toshifumi Wakai; Shujiro Okuda
• Keywords: 0301 basic medicine; Diffuse type; Mutational signature; 03 medical and health sciences; Gastric cancer; Lauren classification; Genomically stable; TP248.13-248.65; Biotechnology; Research Article; 3. Good health

Gastric cancer is one of the most common and clinically important diseases worldwide. The traditional Laeuren classification divides gastric into two histopathological subtypes: diffuse intestinal. Recent genomics research has led to development a new based on molecular characteristics. newly defined genomically stable (GS) subtype shares many cases with histopathologically type. In this study, we performed genetic profiling recurrently significantly mutated genes in type GS tumors. We observed different characteristics, although subtypes overlapped cases. addition, profiles genes, identified functions mutational signatures characteristic each subtype. These results will advance clinical application precision medicine for treating cancer.