Clinical and phytochemical studies of Plantago major in pressure ulcer treatment: A randomized controlled trial

• DOI: 10.1016/j.ctcp.2021.101325
• Publication Date: 2021-01-27T17:07:17Z
• Authors: Masoud Ghiasian; Zahra Niroomandi; Dara Dastan; Jalal Poorolajal; Fateme Zare; Sara Ataei
• Keywords: Phytochemical

Plantago major L. is used by local people to improve various wounds and lesions such as pressure ulcer. In this study, the therapeutic effects of P. major topical formulation on the stage 1 pressure ulcer in patients have been investigated.This randomized triple blind clinical trial study was performed on 130 patients. During the 14 days of study, each of the test and control groups was checked according to check list. Also the topical formulation was standardized by HPLC based on the amount of quercetin.The findings of this study indicated a significant difference in resolution of the damage between the test and control groups. Topical formulation was standardized by HPLC based on the quercetin (1.88 mg/100g) and no side effects associated with this topical formulation was found.The results confirmed the traditional use of P. major in resolution of the damage. CLINICAL TRIAL ID: (IRCT201609209014N117).