Preoperative robotic radiosurgery for early breast cancer: Results of the phase II ROCK trial (NCT03520894)

• DOI: 10.1016/j.ctro.2022.09.004
• Publication Date: 2022-09-22T18:00:10Z
• Authors: Icro Meattini; Giulio Francolini; Vanessa Di Cataldo; Luca Visani; Carlotta Becherini; Erika Scoccimarro; Viola Salvestrini; Chiara Bellini; Laura Masi; Raffaela Doro; Federica Di Naro; Mauro Loi; Giulia Salvatore; Gabriele Simontacchi; Daniela Greto; Marco Bernini; Jacopo Nori; Lorenzo Orzalesi; Simonetta Bianchi; Monica Mangoni; Lorenzo Livi
• Keywords: Cosmesis

Preoperative partial breast irradiation (PBI) has got the advantage of treating a well-defined target. We report results phase II ROCK trial (NCT03520894), enrolling early cancer (BC) patients treated with preoperative robotic radiosurgery (prRS), in terms acute and late toxicity, disease control, cosmesis.The study recruited between 2018 2021 at our Radiation Oncology Unit. Eligible were 50 + years old BC, hormonal receptors positive/human epidermal growth factor receptor 2 negative (HR+/HER2-), sized up to 25 mm. The aimed prospectively assess toxicity feasibility single 21 Gy-fraction prRS setting.A total 70 22 successfully pRS. Overall, three G1 adverse events (13.6 %) recorded within 7 days from prRS. Three 30 days, one G2 oedema two pain. No greater than was recorded. Five experienced toxicity. One patient reported induration. observed. At median follow 18 months (range 6-29.8), cosmetic scored excellent/good fair 14 5 patients, respectively, while 3 poor outcome.ROCK showed that Gy dose represents feasible technique for selected affected by showing an acceptable preliminary profile.