Soluble tumour necrosis factor receptor 1 predicts hospitalization in children and young adults with dengue virus infection in the Philippines

• DOI: 10.1016/j.cyto.2025.156911
• Publication Date: 2025-03-12T03:39:21Z
• Authors: Vanesse Li; Hridesh Mishra; Michelle Ngai; Valerie M. Crowley; Vanessa Tran; Maria Salome Sios...; James Yared Gaite; Patrick Hamilton; Andrea L. Conroy; Kevin C. Kain; Michael T. Hawkes

Dengue fever is a common cause of acute febrile illness in the tropics and requires hospitalization for intravenous (IV) fluid therapy minority patients. Predicting which patients will progress to severe disease challenging. Soluble tumour necrosis factor receptor 1 (sTNFR1) associated with dengue may have prognostic value. Prospective cohort study outpatients Philippines fever, confirmed by NS1 antigenemia or IgM seropositivity. sTNFR1 was measured at presentation were followed 14-21 days (primary outcome), duration stay, IV resuscitation, hemoconcentration, thrombocytopenia (secondary outcomes). 244 (median age 9 years, 40 % female, 26 uncomplicated dengue, 73 warning signs, 0.82 dengue) included. The median plasma concentration 3000pg/mL (IQR 2400-3700) clinic presentation, decreasing 1800 1600-2100) after recovery. 181 (74 %) required hospitalization. Plasma > 2800 pg/mL, subsequent (relative risk 1.5, 95 %CI 1.2-1.7, p < 0.0001). Elevated also longer requirement, thrombocytopenia. marker systemic inflammation (procalcitonin), circulating markers endothelial activation (Ang2, sTie-2, sVCAM-1, endoglin). predictive among DENV infection. It shows promise as that could guide triage reduce large healthcare burden resource-constrained settings.