Puberty contributes to adolescent development of fronto-striatal functional connectivity supporting inhibitory control

• DOI: 10.1016/j.dcn.2022.101183
• Publication Date: 2022-11-29T18:46:45Z
• Authors: Amar Ojha; Ashley C. Parr; William Foran; Finnegan J. Calabro; Beatriz Luna
• Keywords: Inhibitory control

Adolescence is defined by puberty and represents a period characterized neural circuitry maturation (e.g., fronto-striatal systems) facilitating cognitive improvements. Though studies have age-related changes, the extent to which influences of networks less known. Here, we combine two longitudinal datasets characterize role in development resting-state functional connectivity (rsFC) its relationship inhibitory control 106 10–18-year-olds. Beyond age effects, found that was related decreases rsFC between caudate anterior vmPFC, rostral ventral ACC, v/dlPFC, as well with increases dlPFC nucleus accumbens (NAcc) across males females. Stronger vlPFC during early associated worse slower correct responses, respectively, whereas late puberty, stronger dorsal striatum faster responses. Taken together, our findings suggest certain connections are pubertal beyond which, turn control. We discuss implications puberty-related further understanding effects adolescent affective neurodevelopment.