Structural Architecture and Functional Evolution of Wnts
Models, Molecular
Wnt Proteins
0303 health sciences
03 medical and health sciences
Animals
Humans
Protein Structure, Quaternary
Frizzled Receptors
Developmental Biology
Protein Structure, Tertiary
DOI:
10.1016/j.devcel.2012.07.011
Publication Date:
2012-08-13T15:30:39Z
AUTHORS (3)
ABSTRACT
The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds.
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CITATIONS (48)
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