Injectable miniaturized shape-memory electronic device for continuous glucose monitoring

• DOI: 10.1016/j.device.2023.100117
• Publication Date: 2023-10-24T14:29:53Z
• Authors: Kang Jiang; Haiyan Wang; Yanyang Long; Yuxin Han; Heng Zhang; Qunhong Weng
• Keywords: Biocompatible material; Glucose oxidase

Implantable devices hold promise for revolutionizing personalized healthcare, but the inherent invasiveness of implantation surgeries, among other obstacles, hinders their widespread application. In this work, we present an implantable wireless glucose monitor made with on shape-memory electronic device (SMED) that can be implanted minimal invasiveness. The is fabricated by printing inductive-capacitive (LC) circuit and a poly(3-aminophenylboronic acid) (PAPBA)/glucose oxidase (GOx)/graphene oxide (GO) sensing layer poly(D,L-lactide-co-caprolactone)-based (PCLAU) layer. To demonstrate, was rolled up, injected into mice using syringe, later recovered to its original planar shape under mild thermal stimulations. biocompatible SMED has high sensitivity, specificity, reversible characteristics broad linear detection range, providing accurate reliable platform in vivo continuous monitoring. This strategy reduces wound area ∼73% required healing time ∼45%, thus effectively addressing general problem faced devices.