In vitro activity of cefditoren and other antimicrobial agents against 288 Streptococcus pneumoniae and 220 Haemophilus influenzae clinical strains isolated in Zaragoza, Spain

• DOI: 10.1016/j.diagmicrobio.2008.06.007
• Publication Date: 2008-08-21T12:51:26Z
• Authors: Cristina Seral; Laura Suárez; Carmen Rubio-Calvo; Rafael Gómez-Lus; Mercedes Gimeno; Pilar Coronel; Estrella Durán; Raquel Becerril; Mercedes Oca; F. Javier Castillo
• Keywords: Adult; 0301 basic medicine; Haemophilus Infections; Adolescent; Penicillin Resistance; Microbial Sensitivity Tests; Middle Aged; Pneumonia, Pneumococcal; Haemophilus influenzae; Pneumococcal Infections; Anti-Bacterial Agents; Cephalosporins; 3. Good health; 03 medical and health sciences; Streptococcus pneumoniae; Spain; Humans; Respiratory Tract Infections; Aged

In vitro cefditoren antimicrobial activity was tested against 288 Streptococcus pneumoniae and 220 Haemophilus influenzae clinical strains isolated in our hospital from January 2005 to May 2006 by agar dilution and broth microdilution method, respectively. MICs were also determined for 13 and 10 comparison drugs, respectively. The pneumococci tested comprised 113 (39.2%) penicillin susceptible, 91 (31.6%) penicillin intermediate, and 84 (29.2%) penicillin resistant. Cefditoren was the most active drug on the basis of the MICs (MIC(90)=0.5 microg/mL), followed by ceftriaxone and levofloxacin (MIC(90)=1 microg/mL). Cefditoren MICs ranged from 0.25 to 1 microg/mL for ceftriaxone-resistant isolates, with a modal MIC of 0.5 microg/mL and an MIC(90) of 1.0 microg/mL. No S. pneumoniae isolates evaluated in this study showed MICs to cefditoren higher than 1 microg/mL (MIC range, 4 microg/mL). Against H. influenzae (Hi beta+), the rank order of intrinsic activity (MIC(90), microg/mL) was cefditoren (0.03) < cefixime (0.06)8.0).