Characterization of pEncl-30969cz, a novel ColE1-like plasmid encoding VIM-1 carbapenemase, from an Enterobacter cloacae sequence type 92 isolate

• DOI: 10.1016/j.diagmicrobio.2018.01.024
• Publication Date: 2018-02-02T08:35:03Z
• Authors: Costas C. Papagia...; Veronika Paskova; Katerina Chudejova; Matej Medvecky; Ibrahim Bitar; Vladislav Jakubu; Helena Zemlickova; Roman Jirsa; Jaroslav Hrabak
• Keywords: DNA, Bacterial; 0301 basic medicine; Enterobacteriaceae Infections; Microbial Sensitivity Tests; beta-Lactam Resistance; beta-Lactamases; Anti-Bacterial Agents; Integrons; 3. Good health; 03 medical and health sciences; Bacterial Proteins; Enterobacter cloacae; Humans; Plasmids

A VIM-1-producing ST92 Enterobacter cloacae was isolated in a Czech hospital. blaVIM-1 was part of the class 1 integron In110 carried by a Tn1721-like transposon. Tn1721-like was located on a ColE1-like plasmid, pEncl-30969cz (33,003 bp). Target site duplications at the boundaries of Tn1721-like suggested its transposition into the pEncl-30969cz backbone.