Temocillin susceptibility among Enterobacterales strains recovered from blood culture in France

• DOI: 10.1016/j.diagmicrobio.2021.115368
• Publication Date: 2021-03-14T03:38:15Z
• Authors: Eric Farfour; Anne-Gaëlle Si Larbi; Vincent Cattoir; Stéphane Corvec; Thomas Guillard; Antoine Grillon; Christophe Isnard; Audrey Mérens; Nicolas Degand; Typhaine Billard-...; Damien Fournier; Emmanuelle Bille; Cécile Le Brun; Chloé Plouzeau; Emilie Flevin; Nicolas Yin; Paul-Louis Woerther; Julie Lourtet; Philippe Lesprit; Alban Le Monnier
• Keywords: 0301 basic medicine; Extended-spectrum beta-lactamases (ESBL); Antibiotic resistance; [SDV]Life Sciences [q-bio]; MESH: Dose-Response Relationship; Microbial Sensitivity Tests; Penicillins; Third-generation cephalosporin (3GC); MESH: Enterobacteriaceae; 03 medical and health sciences; MESH: Penicillins; environment/Health; Enterobacteriaceae; [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases; MESH: Anti-Bacterial Agents; Drug Resistance, Bacterial; Humans; Cephalosporinase-overproducing strain (COPE); MESH: Enterobacteriaceae Infections; [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology; MESH: Microbial Sensitivity Tests; MESH: Humans; Dose-Response Relationship, Drug; Bacterial; Enterobacteriaceae Infections; Médecine pathologie humaine; [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology; Anti-Bacterial Agents; 3. Good health; MESH: France; [SDV] Life Sciences [q-bio]; [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology; [SDV.EE.SANT]Life Sciences [q-bio]/Ecology; Temocillin; [SDE]Environmental Sciences; [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology; MESH: Drug Resistance; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; France; Drug

Temocillin is used for several years in some European countries but, only since 2015 in France. We assessed the susceptibility of Enterobacterales strains isolated from blood culture 1 year before (2014) and 2 years after (2017) its use in France. 1,387 strains were included by 17 clinical laboratories located throughout France: 363 in 2014 and 1,024 in 2017. The rate of resistance to temocillin was 4.6% and 26.7% in 3rd generation cephalosporin (3GC) susceptible and resistant strains respectively. Cephalosporinase-overproducer (COPE) strains were significantly more resistant to temocillin (37.7%) than ESBL-producer (ESBL-PE) (23.5%) (P < 0.01). The rate of temocillin resistance was correlated to the number of inactive beta-lactams. The rate of resistance to temocillin trend to increase from 13.9% in 2014 to 23.9% in 2017 (P < 0.01). Temocillin remains highly active against Enterobacterales but the trend in resistance should be assessed over time.