Molecular determinants and interaction data of cyclic peptide inhibitor with the extracellular domain of TrkB receptor

• DOI: 10.1016/j.dib.2016.01.016
• Publication Date: 2016-01-16T01:45:44Z
• Authors: Nitin Chitranshi; Vivek Gupta; Yogita Dheer; Veer Gupta; Roshana Vander Wall; Stuart Graham
• Keywords: Docking (animal)

TrkB is a high affinity receptor for the brain derived neurotrophic factor (BDNF) and its phosphorylation stimulates activation of several intracellular signalling pathways linked to cellular growth, differentiation maintenance. Identification various activators inhibitors greater understanding their binding mechanisms critical elucidate biochemical pharmacological analyse protein crystallization studies. The data presented here related research article entitled "Brain Derived involved in regulation glycogen synthase kinase 3β (GSK3β) signalling" [1]. Cyclotraxin B (CTXB) disulphide bridge cyclic peptide molecule that interacts with inhibits BDNF/TrkB downstream signalling. This reports first time mechanism interaction parameters CTXB receptor. molecular model has been generated it's docking domain carried out determine residues interaction.