A transcriptomic dataset evaluating the effect of radiotherapy injury on cells of skin and soft tissue

• DOI: 10.1016/j.dib.2022.107828
• Publication Date: 2022-01-14T15:23:49Z
• Authors: Lipi Shukla; Stuart A. Lee; Mei R.M. Du; Tara Karnezis; Matthew E. Ritchie; Ramin Shayan
• Keywords: Human skin; Lymphatic Endothelium

Radiotherapy injury to cells of the skin and subcutaneous tissue is an inevitable consequence external beam radiation for treatment cancer. This sublethal normal tissues plays a significant role in development fibrosis, lymphedema, impaired wound healing, recurrent infections. To elucidate transcriptional changes that occur soft after radiotherapy injury, we performed genome-wide RNA-sequencing comparing irradiated (10Gy) with non-irradiated (0Gy) controls human dermal fibroblasts, keratinocytes, microvascular endothelial cells, lymphatic pericytes adipose derived stem cell populations. These data are publicly available from Gene Expression Omnibus database (accession number GSE184119). Further insights can be gained by mRNA signatures arising these other studies involving similar or different types. global targets hold potential manipulation mitigate injury.