Microarray transcriptome datasets of maternal-zygotic DNA methyltransferase 3aa−/− zebrafish during early developmental stages

• DOI: 10.1016/j.dib.2023.108967
• Publication Date: 2023-02-09T06:30:01Z
• Authors: Masaki Shirai; Nobuyoshi Shimoda; Haruko Takahashi; Kazuya Takayama; Yutaka Kikuchi
• Keywords: 0301 basic medicine; Q1-390; 03 medical and health sciences; Science (General); Computer applications to medicine. Medical informatics; R858-859.7; Epigenetics; Microarray; Development; Dnmt3aa; Zebrafish; Data Article

DNA methylation is an epigenetic regulator mediated by methyltransferases (Dnmts). The involved in control of gene expression vertebrates. It has been reported that there are mainly two types de novo Dnmts, Dnmt3a and Dnmt3b, mammals. These Dnmts function the distinct or overlapping genomic regions. zebrafish homologs mammalian Dnmt3aa Dnmt3ab. We generated a maternal-zygotic dnmt3aa deficient mutant (MZdnmt3aa) to identify specific target regions for genome their developmental process. Microarray analysis revealed alterations knock-out early development. datasets were produced from samples at five different stages: 1-2 cell, shield, 5-somite, 1-day post fertilization (dpf), 2 dpf. Herein, we present novel raw processed transcriptome MZdnmt3aa-/- mutant. microarray data available through Gene Expression Omnibus (GEO), accession number GSE202646. may be useful comparing differences among species mutants analyzing human diseases caused DNMT3A such as acute myelogenous leukemia (AML).