Potential of postbiotics for the treatment of metabolic disorders

• DOI: 10.1016/j.drudis.2024.103921
• Publication Date: 2024-02-20T02:52:50Z
• Authors: Neeraj Mishra; Ashish Garg; Sumel Ashique; Shvetank Bhatt
• Keywords: Dysbiosis; Flora

Postbiotics, the next generation of probiotics, are extracts that are free of living and nonviable bacteria and show strong modulatory effects on the gut flora. Examples include vitamin B12, vitamin K, folate, lipopolysaccharides, enzymes, and short-chain fatty acids (SCFAs), representing a subset of essential nutrients commonly found in the human diet. Postbiotics have been observed to demonstrate antiobesity and antidiabetic effects through a variety of mechanisms. These pathways primarily involve an elevation in energy expenditure, a decrease in the formation and differentiation of adipocytes and food intake, modification of lipid and carbohydrate absorption and metabolism, and regulation of gut dysbiosis. Based on these above effects and mechanisms, the use of postbiotics can be considered as potential strategy for the treatment of metabolic disorders.