Sub-optimal neutralisation of omicron (B.1.1.529) variant by antibodies induced by vaccine alone or SARS-CoV-2 Infection plus vaccine (hybrid immunity) post 6-months

• DOI: 10.1016/j.ebiom.2022.103938
• Publication Date: 2022-03-16T04:15:14Z
• Authors: Guruprasad R Medi...; Gaurav Batra; Deepika Rathna Mu...; Ramachandran Thir...; Souvick Chattopad...; Bhabatosh Das; Mudita Gosain; Ayushi; Janmejay Singh; Anantharaj Anbalagan; Heena Shaman; Kamal Pargai; Farha Mehdi; Soon Jyoti Das; Namrata Kahlon; Savita Singh; Pallavi Kshetrapal; Nitya Wadhwa; Anil K Pandey; Shinjini Bhatnagar; Pramod Kumar Garg
• Keywords: Medicine (General); 0303 health sciences; COVID-19 Vaccines; Omicron; SARS-CoV-2; R; COVID-19; Articles; Live-virus neutralisation; 3. Good health; Covishield; 03 medical and health sciences; R5-920; Cross-Sectional Studies; Vaccines, Inactivated; ChAdOx1 nCoV-19; Covaxin; Medicine; Humans

Rapid spread of the omicron SARS-CoV-2 variant despite extensive vaccination suggests immune escape. The neutralising ability different vaccines alone or with natural infection against is not well-known.In this cross-sectional study, we tested vaccine and induced antibodies to neutralise in a live virus neutralisation assay four groups individuals: (i) ChAdOx1 nCoV-19 vaccination, (ii) plus prior infection, (iii) inactivated (BBV152), (iv) BBV152 infection. Primary outcome was fold-change titre compared ancestral virus.We included 80 subjects. geometric mean (GMT) 50% focus reduction test (FRNT50) 380·4 (95% CI: 221·1, 654·7) 379·3 185·6, 775·2) nCov-19 alone. GMT for were 806·1 478·5, 1357·8) 1526·2 853·2, 2730·0), respectively. Against variant, only 5 out 20 both groups, 6 group, 9 group exhibited titres above lower limit quantification (1:20) suggesting better A 26·6 25·7 fold FRNT50 Omicron strain observed individuals without vaccinated nCoV-19, corresponding 57·1 58·1 fold, respectively, demonstrated moderate correlation serum anti-RBD IgG levels [Spearman r: 0·58 (0·41, 0·71)].Significant vaccine-induced infection-induced which might explain escape.Department Biotechnology, India; Bill & Melinda Gates Foundation, USA.