Air pollution and risk of chronic obstructed pulmonary disease: The modifying effect of genetic susceptibility and lifestyle

• DOI: 10.1016/j.ebiom.2022.103994
• Publication Date: 2022-04-10T03:15:49Z
• Authors: Lulin Wang; Junqing Xie; Yonghua Hu; Yaohua Tian
• Keywords: Interquartile range

The effect of long-term exposure to air pollution on the development chronic obstructive pulmonary disease (COPD) is still controversial, and role interactions with genetic risk lifestyle in COPD unclear.We included 452762 participants derived from UK Biobank. Annual concentrations pollutions, including particle matter (PM2.5, PM10), nitrogen oxides (NOx), dioxide (NO2), were assessed using land-use regression model. We applied Cox proportional hazard model evaluate associations between risk. In addition, we constructed a polygenic score score, whether susceptibility modified risk.Each interquartile range (IQR) increase annual PM2.5, PM10, NOx, NO2 was associated 1.17 (95% CI: 1.15,1.19), 1.05 1.03,1.06), 1.13 1.11,1.14), 1.19 1.16,1.21) times COPD, respectively. observed an additive interaction PM2.5 (P-interact=0.095), negative (P-interact=0.062). HRs for each IQR 1.21, 1.16-1.25) 1.24, 1.21-1.26) individuals healthy unfavourable lifestyle, respectively; 1.16, 1.13-1.19) 1.19, 1.16-1.22) those low high risk, Participants exposure, showed highest COPD.Long-term increased especially lifestyle.None.