Comparison of 25-hydroxy vitamin D serum levels among children with epilepsy in therapy with single versus multiple antiseizure medications

• DOI: 10.1016/j.ebr.2023.100620
• Publication Date: 2023-08-26T15:40:39Z
• Authors: Prastiya Indra Gu...; Nur Rochmah; Muhammad Faizi
• Keywords: Antiseizure medication; Neurophysiology and neuropsychology; Epilepsy; QP351-495; 25-Hydroxy vitamin D; Disease; Neurology. Diseases of the nervous system; RC346-429; Article; 3. Good health

Treatment with antiseizure medications (ASMs) for more than 6 months requires monitoring of side effects, one which is a decreased level serum vitamin D. This study aimed to compare the influence therapies versus multiple ASMs on 25-hydroxy D (25-OHD) levels among children epilepsy.Our cross-sectional comparative was conducted in Paediatric Neurology Clinic at Soetomo Academic Hospital. Epileptic aged 2-18 years who had been using least were enrolled and grouped according whether they taking single or ASMs. The mean 25-OHD both groups compared Welch t-test (95% confidence interval).Among 60 enrolled, deficiency identified 13% ASM 53% ones ASMs; 26.6 (SD 5.29) ng/mL 20.2 4.25) ng/mL, respectively. There significant difference between (p = 0.001).Patients have lower expected their age, those having lowest levels.