Association of exposure to per- and polyfluoroalkyl substances with hemoglobin and hematocrit during pregnancy

• DOI: 10.1016/j.ecoenv.2022.114319
• Publication Date: 2022-11-21T22:11:36Z
• Authors: Fengzhen Cui; Hongxiu Liu; Yuanyuan Li; Tong-Zhang Zheng; Shunqing Xu; Wei Xia; Xia Sheng
• Keywords: Cord blood

Per- and polyfluoroalkyl substances (PFASs) are common environmental contaminants widely detected in humans. Previous studies have linked PFASs exposure to adverse birth outcomes. However, the association between maternal hemoglobin (Hb) hematocrit (HCT) remains unclear. We aimed explore relationship with Hb HCT during pregnancy. The present cohort study included 1044 pregnant women from Wuhan, China. Maternal were measured first, second third trimesters, 13 cord sera. Mixed linear models general regression applied analyze each single HCT. Weighted quantile sum (WQS) regressions used investigate mixture In single-PFAS models, 10 positively associated across pregnancy (a 10-fold increase was 1.47–3.54 % change 1.46–3.20 (All P-FDR < 0.05). addition, more related trimesters rather than first trimester. not significant iron supplementation group, whereas non-iron group. A interaction also detected. WQS showed that perfluorononanoic acid (PFNA) perfluorohexane sulfonate (PFHxS) contributed most respectively. positive serum Moreover, may play a modifying effect influencing Hb.