Triptolide exposure triggers testicular vacuolization injury by disrupting the Sertoli cell junction and cytoskeletal organization via the AKT/mTOR signaling pathway

• DOI: 10.1016/j.ecoenv.2024.116502
• Publication Date: 2024-05-24T00:38:39Z
• Authors: Xiwen Yang; Lei He; Xinyao Li; Lingling Wang; Tiao Bu; Damin Yun; Xinran Lu; Sheng Gao; Qiuru Huang; Jiaxin Li; Bo Zheng; Jun Yu; Fei Sun
• Keywords: Vacuolization; Triptolide

Despite the known reproductive toxicity induced by triptolide (TP) exposure, regulatory mechanism underlying testicular vacuolization injury caused TP remains largely obscure.