Synthesis and cytotoxic activity of substituted 2-phenyl-3-hydroxy-4(1H)-quinolinones-7-carboxylic acids and their phenacyl esters

• DOI: 10.1016/j.ejmech.2005.12.008
• Publication Date: 2006-03-16T12:17:02Z
• Authors: Miroslav Soural; Jan Hlaváč; Pavel Hradil; Iveta Fryšová; Marián Hajdúch; Valerio Bertolasi; Michal Maloň
• Keywords: quinolinone; cytotoxic activity; X-ray structure; TOPOISOMERASE-II; CELLS; Models, Molecular; Magnetic Resonance Spectroscopy; Carboxylic Acids; Biological Availability; Tetrazolium Salts; Antineoplastic Agents; Esters; Crystallography, X-Ray; 01 natural sciences; 0104 chemical sciences; 3. Good health; Structure-Activity Relationship; Thiazoles; Cell Line, Tumor; Quinolines; Humans; Indicators and Reagents; Drug Screening Assays, Antitumor

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