New pyrazoline derivatives and their antidepressant activity

• DOI: 10.1016/j.ejmech.2010.06.011
• Publication Date: 2010-06-14T08:31:06Z
• Authors: Zafer Asım Kaplan...; Ahmet Özdemir; Gülhan Turan-Zitouni; Mehlika Dilek Alt...; Özgür Devrim Can
• Keywords: Male; Behavior, Animal; Triazoles; Pyrazoline; 01 natural sciences; Rota-Rod; Antidepressive Agents; 0104 chemical sciences; 3. Good health; Mice; Modified Forced Swimming Test; Tail Suspension Tests; Animals; Pyrazoles; Triazole; Antidepressant Activity

Some triazolo-pyrazoline derivatives were synthesized to investigate their potential antidepressant activities. The chemical structures of the compounds were elucidated by IR, NMR and FAB(+)-MS spectral data and elemental analyses. Antidepressant-like activities of the test compounds (100 mg/kg) were screened using both modified forced swimming and tail suspension tests. Rota-Rod test was performed for the examination of probable neurological deficits due to the test compounds, which may interfere with the test results. The test compounds in the series exhibited different levels of antidepressant activities when compared to reference drug fluoxetine. None of the test compounds changed motor coordination of animals when assessed in the Rota-Rod test. Therefore, experimental results in this study were not interfered with motor abnormalities.