New quinolin-4-yl-1,2,3-triazoles carrying amides, sulphonamides and amidopiperazines as potential antitubercular agents

• DOI: 10.1016/j.ejmech.2011.03.039
• Publication Date: 2011-04-15T18:55:34Z
• Authors: K.D. Thomas; Airody Vasudeva A...; Imran H. Chowdhury; E. Sumesh; Nishith K. Pal
• Keywords: Models, Molecular; 0301 basic medicine; Dose-Response Relationship, Drug; Molecular Structure; Antitubercular Agents; Streptococcus; Stereoisomerism; Microbial Sensitivity Tests; Triazoles; Crystallography, X-Ray; Amides; 01 natural sciences; Piperazines; 0104 chemical sciences; 3. Good health; Structure-Activity Relationship; 03 medical and health sciences; Pseudomonas; Escherichia coli; Quinolines

AbstractAmong the synthesized compounds, compounds (IXa), (IXc)—(IXe), (XIc), (XVa) and (XVd) show significant antitubercular activity when compared to isoniazid.