The conversion of oridonin to spirolactone-type or enmein-type diterpenoid: Synthesis and biological evaluation of ent-6,7-seco-oridonin derivatives as novel potential anticancer agents

• DOI: 10.1016/j.ejmech.2012.03.024
• Publication Date: 2012-03-23T00:45:39Z
• Authors: Lei Wang; Dahong Li; Shengtao Xu; Hao Cai; Hequan Yao; Yihua Zhang; Jieyun Jiang; Jinyi Xu
• Keywords: 0301 basic medicine; Antineoplastic Agents; Chemistry Techniques, Synthetic; Spironolactone; Xenograft Model Antitumor Assays; 3. Good health; Mice; Structure-Activity Relationship; 03 medical and health sciences; Animals; Humans; Female; Diterpenes; Diterpenes, Kaurane; K562 Cells

AbstractThe conversion of oridonin (I) to spirolactone‐type (III) or enmein‐type diterpenoid (VI) and (VII) is conducted as well as spirolactone‐type diterpenoid to enmein‐type diterpenoid.