2-Anilino-4-(benzimidazol-2-yl)pyrimidines – A multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines

• DOI: 10.1016/j.ejmech.2012.04.007
• Publication Date: 2012-04-14T15:24:14Z
• Authors: Renate Determann; Jan Dreher; Knut Baumann; Lutz Preu; Peter G. Jones; Frank Totzke; Christoph Schächtele; Michael H.G. Kubb...; Conrad Kunick
• Keywords: Benzimidazole; Cancer cell lines

AbstractHitherto unknown title compounds of the general structure (III) are obtained by reaction of benzimidazole‐substituted enaminones (I) with suitable arylguanidinium nitrates (II).