Benzodioxane–benzamides as new bacterial cell division inhibitors

• DOI: 10.1016/j.ejmech.2014.09.100
• Publication Date: 2014-10-18T09:37:47Z
• Authors: Giuseppe Chiodini; Marco Pallavicini; Carlo Zanotto; Massimiliano Bissa; Antonia Radaelli; Valentina Straniero; Cristiano Bolchi; Laura Fumagalli; Paola Ruggeri; Carlo De Giuli Mo...; Ermanno Valoti
• Keywords: FtsZ; Residue (chemistry)

A SAR study was performed on 3-substituted 2,6-difluorobenzamides, known inhibitors of the essential bacterial cell division protein FtsZ, through a series of modifications first of 2,6-difluoro-3-nonyloxybenzamide and then of its 3-pyridothiazolylmethoxy analogue PC190723. The study led to the identification of chiral 2,6-difluorobenzamides bearing 1,4-benzodioxane-2-methyl residue at the 3-position as potent antistaphylococcal compounds.