Discovery of novel sesquistilbene indanone analogues as potent anti-inflammatory agents

• DOI: 10.1016/j.ejmech.2016.02.021
• Publication Date: 2016-02-08T17:53:24Z
• Authors: Mei-Lin Tang; Chen Zhong; Zheng-Yu Liu; Peng Peng; Xin-Hua Liu; Xun Sun
• Keywords: Anti-inflammatory

To develop novel anti-inflammatory agents with improved pharmaceutical profiles, twenty-eight novel sesquistilbene indanone analogues were synthesized and evaluated for anti-inflammatory activity using RAW264.7 cells. Among these compounds, compound 11k was found to be one of the most potent analogues in inhibiting NO production in LPS-stimulated RAW264.7 cells. Furthermore, it could also significantly suppress LPS-induced iNOS and COX-2 expression and NO production through TLR4/JNK/NF-κB signaling pathway in a concentration dependent manner.