Biological evaluation of indolizine-chalcone hybrids as new anticancer agents

• DOI: 10.1016/j.ejmech.2017.12.056
• Publication Date: 2017-12-19T08:17:03Z
• Authors: Sujin Park; Eun Hye Kim; Jinwoo Kim; Seong Hwan Kim; Ikyon Kim
• Keywords: Chalcone; Indolizine; Aldol condensation

A new chemical space was explored based on an indolizine-chalcone hybrid, which was readily accessible by base-mediated aldol condensation of indolizine bearing a 7-acetyl group with various (hetero)aromatic aldehydes. Their anticancer effect was evaluated, revealing that indolizine-chalcone hybrids with 3,5-dimethoxyphenyl group (4h) or the halogen at the meta position (4j and 4l) could have the potential to induce the caspase-dependent apoptosis of human lymphoma cells.