Synthesis and evaluation of novel furanones as biofilm inhibitors in opportunistic human pathogens

• DOI: 10.1016/j.ejmech.2022.114678
• Publication Date: 2022-08-20T23:15:29Z
• Authors: Andromeda-Celeste...; Thérèse Lyons; Uwe Mamat; Daniel Yero; Marc Bravo; Xavier Daura; Osama Elshafee; Sascha Brunke; Cormac G.M. Gahan; Michelle O'Driscoll; Isidre Gibert; Timothy P. O'Sull...
• Keywords: Galleria mellonella; Human pathogen; Opportunistic pathogen

Diseases caused by biofilm-forming pathogens are becoming increasingly prevalent and represent a major threat to human health. This trend has prompted search for novel inhibitors of microbial biofilms which could, example, be used potentiate existing antibiotics. Naturally-occurring, halogenated furanones isolated from marine algae have proven effective biofilm in several bacterial species. In this work, we report the synthesis library their subsequent evaluation as opportunistic including S. enterica, aureus, E. coli, maltophilia, P. aeruginosa C. albicans. A number most potent compounds were subjected further analysis confocal laser-scanning microscopy effects on albicans individually, addition mixed polymicrobial biofilms. Lastly, investigated impact promising candidate survival rates vivo using Galleria mellonella model.