Cannabinoid receptor antagonist reduces heroin self-administration only in dependent rats

• DOI: 10.1016/j.ejphar.2004.08.022
• Publication Date: 2004-09-21T18:24:21Z
• Authors: Miguel Navarro; M. Rocio A. Carrera; Ignacio del Arco; Jose Manuel Trigo; George F. Koob; Fernando Rodrígue...
• Keywords: Opiate; Self-administration; Cannabinoid receptor antagonist

Functionality of the endogenous cannabinoid system undergoes relevant changes in reward-related brain areas in animal models of opiate addiction. By using a limited access heroin self-administration paradigm we show that cannabinoid CB(1) receptor antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride (SR141716A, 0.03-3.0 mg/kg) suppresses heroin self-administration only in opiate-dependent rats but not in non-dependent animals. These results further support the study of cannabinoid CB(1) receptor antagonists for the treatment of opiate addiction.