Treatment of metastatic lung cancer via inhalation administration of curcumin composite particles based on mesoporous silica

• DOI: 10.1016/j.ejps.2019.04.025
• Publication Date: 2019-04-26T12:10:31Z
• Authors: Wenqiang Su; Tongxin Wei; Manqi Lu; Zhiping Meng; Xuanyu Chen; Jie Jing; Junsong Li; Weiwei Yao; Huaxu Zhu; Tingming Fu
• Keywords: Drug Carriers; 0303 health sciences; Curcumin; Lung Neoplasms; Cell Culture Techniques; Biological Availability; Silicon Dioxide; 3. Good health; Mice, Inbred C57BL; Mice; 03 medical and health sciences; RAW 264.7 Cells; Phagocytosis; Solubility; Administration, Inhalation; Models, Animal; Animals; Humans; Neoplasm Metastasis; Particle Size

Curcumin attracted attention due to its promising anti-cancer properties and safety performance. However, its poor aqueous solubility and low bioavailability have to be overcome before it goes into clinic use. Here, porous composite particles are prepared by loading curcumin into mesoporous material SBA-15, and its therapeutic effect on lung cancer via inhalation administration have also been evaluated. The inclusion of curcumin in host material SBA-15 was confirmed by the reduced surface area and pore diameter of the composite material, and the aerodynamic performance of the composite material was investigated by FT-4 and NGI. Phagocytosis experiments on RAW264.7, the toxicity of material extracts on BEAS-2B cells, and the haemolysis experiments showed that the mesoporous materials had good biocompatibility at 10-400 μg/mL. The B16F10 melanoma metastatic lung mouse model was used to investigate the therapeutic effect of lung cancer after inhalable administration. It was found that the body weight of the curcumin composite particle-administered group decreased more slowly and the lung disease developed slower than the curcumin crude drug group, indicating that the composite particles has a certain inhibitory effect on tumours.