Sustained dual release of ciprofloxacin and lidocaine from ionic exchange responding film based on alginate and hyaluronate for wound healing

PAIN MANAGEMENT Staphylococcus aureus Wound Healing FLUOROQUINOLONES Alginates Lidocaine POLYELECTROLYTE, ALGINATE 02 engineering and technology Anti-Bacterial Agents Ciprofloxacin HYALURONATE https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 0210 nano-technology ANTIBIOTIC SMART WOUND DRESSINGS
DOI: 10.1016/j.ejps.2021.105789 Publication Date: 2021-03-07T10:46:40Z
ABSTRACT
This study presents a new antibiotic-anesthetic film (AA-film) based on natural polyelectrolytes ionically complexed with lidocaine and ciprofloxacin to manage pain associated with infected wounds. The rational selection of the components resulted in the AA-films being transparent, compatible with wound skin pH and highly water vapor permeable. The drug release properties evaluated in saline solution and water revealed an ionic exchange mechanism for the release of both drugs and showed that ciprofloxacin acts as a cross-linker, as was confirmed by rheological evaluation. The in vitro antimicrobial efficacy against S. aureus and P. aeruginosa was demonstrated. Furthermore, AA-films exhibit a high fluid absorption capacity and act as a physical barrier for microorganisms. This work highlights the great potential of this smart system as an attractive dressing for skin wounds, surpassing currently available treatments.
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