Pharmaceutical 3D-printing of nanoemulsified eucalypt extracts and their antimicrobial activity

• DOI: 10.1016/j.ejps.2023.106487
• Publication Date: 2023-06-03T06:01:41Z
• Authors: Oleh Koshovyi; Jyrki Heinämäki; Ain Raal; Ivo Laidmäe; Niklas Sandler To...; Mykola Komisarenko; Andrey Komissarenko
• Keywords: 3d printed; Phytochemical

Overcoming the health threatening consequences of staphylococcal infections and their negative socio-economic effects have become a priority in medical, pharmaceutical, food many other sectors globally. Staphylococcal are big challenge for global care, since they difficult to be diagnosed treated. Therefore, development new medicinal products plant-origin is timely important, because bacteria limited ability develop resistance such products. In present study, modified eucalypt (Eucalyptus viminalis L.) extract was prepared further enhanced by using different excipients (surface active agents) obtain water-miscible 3D-printable (nanoemulsified aqueous extract). Phytochemical antibacterial studies leaves extracts were conducted as preliminary investigation 3D-printing experiments extracts. The nanoemulsified mixed with polyethylene oxide (PEO) form gel applicable semi-solid extrusion (SSE) 3D printing. key process parameters identified verified. printing quality 3D-lattice type preparations very good, demonstrating feasibility an SSE also exhibiting compatibility carrier polymer plant extract. 3D-printed presented rapid dissolution water within 10-15 min, suggesting applicability these e.g., oral immediate-release applications.