Dual stimuli-responsive mesoporous silica nanoparticles for efficient loading and smart delivery of doxorubicin to cancer with RGD-integrin targeting

• DOI: 10.1016/j.ejps.2023.106525
• Publication Date: 2023-07-11T01:01:43Z
• Authors: Han-Sem Kim; Ji-Hye Kang; JunHwee Jang; Eun-Jung Lee; Jin Hee Kim; Jonghoe Byun; Ueon Sang Shin
• Keywords: Nanocarriers; Doxorubicin Hydrochloride

The recent progress in nanoparticle applications, such as tumor-targeting, has enabled specific delivery of chemotherapeutics to malignant tissues with enhanced local efficacy while limiting side effects. However, existing systems leave much room for improvement terms achieving colloidal stability fluid medium, efficient targeting intended sites, and effective release therapeutic drugs into diseased cells. Here, an stimuli-responsive nanocarrier mammalian cells, termed RGD-NAMs, was developed, which temperature- pH-sensitive drug loads. RGD-NAMs comprise two parts: a copolymer shell (NIBIm-AA-RGD) drug-container core (MSNs). have stable drug-loading capacity marked difference the rate depending on temperature pH conditions. also exhibit high SBF (Stimulated body fluid) solutions minimal toxicity skeletal myoblasts (C2C12) bovine arterial endothelial cells (BAEC). doxorubicin-loaded induced cytotoxic effect dose-dependent manner, furthered by increase from 37 40 °C. Moreover, significant control amount were achieved through change. This novel, smart drug-delivery system responsiveness changes wide application prospects biomedical fields, including theragnosis tumors vascular diseases.